Pinealon (Glu-Asp-Arg) CNS Bioregulator | High Purity

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) that has been investigated extensively for its potential as a central nervous system (CNS) bioregulator. It belongs to a class of synthetic peptide preparations derived from natural regulatory peptides, often used in research for their potential modulatory effects on various physiological systems.

Description

Pinealon is a synthetic tripeptide investigated for its neuroprotective, antioxidant, and gene-regulating properties within the central nervous system. Its sequence, Glu-Asp-Arg (Glutamic acid, Aspartic acid, Arginine), is designed to mimic or modulate the activity of endogenous regulatory peptides, particularly those involved in brain function and aging processes.

This compound is primarily studied for its potential to support neuronal health, improve cognitive function, and protect brain tissue from various stressors, including oxidative damage and ischemia. The research often focuses on its ability to influence specific brain peptide systems and gene expression profiles related to neuronal plasticity and survival.

Physicochemical Properties

The following table summarizes the key physicochemical characteristics of Pinealon in its synthesized form:

CAS Number

158308-41-5

Molecular Formula

C15H27N5O8

Molecular Weight

405.41 g/mol

Form

Crystalline Powder

Solubility

Soluble in water

Target

Neuronal DNA / NMDA Receptors

Proposed Mechanism of Action

Research suggests that Pinealon exerts its biological effects through several proposed mechanisms within the CNS:

1. Gene-Regulating Activity

One of the primary theories surrounding Pinealon is its potential to interact with and modulate gene expression in brain tissues. Studies have indicated that it may influence the transcription of genes related to brain-derived neurotrophic factor (BDNF), antioxidant enzymes, and other proteins crucial for neuronal survival and differentiation. This interaction is believed to occur via sequence-specific binding or through signaling pathways that ultimately affect DNA transcription.

2. Neuroprotective Effects

Pinealon is frequently studied for its ability to protect neurons from damage caused by various pathological conditions, such as:

• Oxidative Stress: The peptide may enhance the activity of endogenous antioxidant systems, reducing the damage caused by reactive oxygen species (ROS) that accumulate during stress or aging.
• Ischemia and Hypoxia: In models of reduced blood flow or oxygen deprivation, Pinealon has been shown to potentially limit neuronal cell death, suggesting a role in improving neuronal tolerance to these conditions.
• Excitotoxicity: There is evidence suggesting Pinealon may modulate the activity of neurotransmitter receptors, such as NMDA receptors, potentially mitigating the damage caused by excessive excitatory signaling (excitotoxicity).

3. Modulation of Brain Peptide Systems

As a synthetic peptide, Pinealon may interact with or mimic the function of natural neuroactive peptides. This modulation could help restore balance in impaired peptide systems, which are often implicated in age-related cognitive decline and neurodegenerative disorders.

Research Applications

Pinealon is an agent of interest across various fields of preclinical research, including:

• Gerontology Research: Investigating its potential role in slowing down or mitigating age-related changes in brain function and structure.
• Neuroscience: Studying its impact on learning, memory, and synaptic plasticity.
• Toxicology: Exploring its protective capacity against neurotoxin-induced damage.
• Psychopharmacology: Assessing its ability to influence mood regulation and behavior in various animal models.

The goal of this research is to understand the fundamental mechanisms by which synthetic regulatory peptides can support CNS function and potentially offer therapeutic strategies for CNS disorders.

Handling Precautions

1. Reconstitution: Before use, allow the powder to reach room temperature in a desiccator to prevent condensation.
2. Solvent: Reconstitute with sterile, high-purity water (for aqueous solutions) or as dictated by the specific experimental protocol.
3. Sterility: All handling should be performed under aseptic conditions to prevent microbial contamination, especially for solutions intended for in vivo research.
4. Safety: Standard laboratory safety procedures should be followed, including the use of appropriate personal protective equipment (PPE), such as gloves, lab coat, and eye protection.

Quality Control and Purity

The Pinealon offered is synthesized to ensure high purity and consistency for research applications.

Purity Assurance:

• HPLC (High-Performance Liquid Chromatography): Purity is typically verified to be >98%.
• Mass Spectrometry (MS): Used to confirm the correct molecular weight and structure (C15H27N5O8).
• Amino Acid Analysis: Confirms the correct ratio of Glutamic acid, Aspartic acid, and Arginine.

The product is supplied as a white lyophilized powder, ensuring maximal stability for long-term storage under recommended conditions.

References and Further Reading

The study of synthetic regulatory peptides is an evolving field. Users interested in the source material and peer-reviewed studies related to Pinealon's biological activity are encouraged to review contemporary scientific literature. Key search terms include:

• Pinealon tripeptide
• Glu-Asp-Arg neuroprotection
• CNS regulatory peptides
• Peptide bioregulation in the brain

The provided information is for research purposes only. This product is not intended for human consumption or therapeutic use. Researchers must ensure compliance with all applicable local and international regulations regarding the handling and use of research chemicals.